The site allows users to customize and create all kinds of goods such as T-shirts, drinkware, stationery and more.
The company, which was founded in 1999, hopes to raise $80 million in the IPO.
In its filing, CafePress stated it has seen more than 325 million unique products sold through its site since its inception. The company also reported $128 million in revenue and $2.7 million in profit for last year.
CafePress would be the latest ins a string of high-profile tech IPOs. Last month, LinkedIn's IPO dominated headlines, as well as raising the personal worth of its founders and leaving the company valued at around $9 billion.
Last week, daily deals coupon app maker Groupon filed for a $750 million IPO. And web-based radio startup Pandora filed with the SEC back in February.